General
Preferred name
DEFACTINIB
Synonyms
VS-6063 ()
PF-04554878, VS-6063, Defactinib Hydrochloride ()
PF-04554878 ()
VS-6063 hydrochloride ()
PF 04554878 hydrochloride ()
DEFACTINIB HYDROCHLORIDE ()
Defactinib (hydrochloride) ()
Defactinib (VS-6063) ()
VS-6063 HYDROCHLORIDE ()
Defacitinib ()
P&D ID
PD012994
CAS
1073154-85-4
1345713-71-4
1073160-26-5
Tags
available
free of charge
probe
drug
drug candidate
Drug indication
Ovarian cancer
Solid tumour/cancer
Malignant pleural mesothelioma
non-small cell lung carcinoma
Pancreatic cancer
Mesothelioma
Drug Status
approved
investigational
Max Phase
2.0
3.0
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
High-quality chemical probes
Open Science Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Defactinib (VS-6063) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities .
DESCRIPTION Defactinib (VS-6063) is an orally bioavailable, second generation, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities . (GtoPdb)
DESCRIPTION Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities.
PRICE 87
DESCRIPTION Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
PRICE 99
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION Potent BRAF and CRAF inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Defactinib (VS-6063) is a second-generation inhibitor of FAK that inhibits FAK phosphorylation at the Tyr397 site. Defactinib has potential antitumor activity. (TargetMol Bioactive Compound Library)
DESCRIPTION Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK. Which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. (TargetMol Bioactive Compound Library)
Cell lines
13
Organisms
0
Compound Sets
22
AdooQ Bioactive Compound Library
A11929
Axon Medchem Screening Library
2574
Cayman Chemical Bioactives
17737
ChEMBL Drugs
CHEMBL3137331
CHEMBL3137305
Chemical Probes.org
defactinib
Clinical kinase drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB12282
DrugMAP
DMGBLI3
EU-OPENSCREEN Bioactive Compound Library
EOS101806
EUbOPEN Chemogenomics Library
EUB0000138
Guide to Pharmacology
7910
High-quality chemical probes
PD012994
LINCS compound set
10621-101
MedChem Express Bioactive Compound Library
HY-12289
HY-12289A
Open Science Probes
PF-04554878
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
defactinib
TargetMol Bioactive Compound Library
T1996
T15092
Tocris Bioactive Compound Library
7305
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
510.14
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
3
cLogP
2.4
TPSA
142.1
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
PTK2
Target
FAK
Ligand for Target Protein
FAK/PYK2 inhibitor
PTK2, PTK2B
PTK2B
Primary Target
Focal Adhesion Kinase
MOA
Inhibitor
focal adhesion kinase inhibitor
Targeted domain
Kinase domain
Pathway
Protein Tyrosine Kinase/RTK
Angiogenesis
Cytoskeletal Signaling
Tyrosine Kinase/Adaptors
Control name
PF-00911705
Target class
Kinase, Kinase
Target subclass
TK, TK
Recommended Cell Concentration
100 nM
Source data